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To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early

NCT00361517 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2018-09-26

No results posted yet for this study

Summary

Chemotherapy lowers the white blood cell count or weakens the immune system for a long time. This puts the patients at a high risk of getting a serious fungal infection of the internal organs or blood. One of these infections is caused by a mold called Aspergillus and can be life threatening. Usually doctors give preventive antifungal therapy to try to lower the risk of this infection. Despite this, patients are still at risk of getting fungal infection. This study is thus designed to test Galactomannan - a component of cell wall of Aspergillus and hence detect and treat fungal infection early.

Conditions

  • Aspergillosis

Interventions

BEHAVIORAL

Galactomannan antigen monitoring, Aspergillus PCR

There will be blood draws twice weekly for monitoring GM antigen and once a week for Aspergillus PCR.

OTHER

blood draws

Blood is drawn for monitoring of Galactomannan antigen in the blood

OTHER

blood draws for GM monitoring

blood samples will be taken twice weekly for monitoring of GM antigen levels in the blood and once a week for Aspergillus PCR.

DRUG

Amphotericin-B deoxycholate

1-1.5mg/kg, i.v, once a day

OTHER

blood test

Blood will be tested twice a week for the presence of Galactomannan.

OTHER

Blood test

Blood will be drawn twice a week and it will be tested for the presence of GM(a component of the cell wall of the mold Aspergillus which is released during growth)

Sponsors & Collaborators

  • National University Hospital, Singapore

    collaborator OTHER

  • Singapore General Hospital

    lead OTHER

Principal Investigators

  • Ban H Tan, Dr · Singapore General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-06-01
Primary Completion
2007-10-30
Completion
2009-06-30

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00361517 on ClinicalTrials.gov