Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy
NCT00348530 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2006-10-18
Summary
Accumulated clinical and experimental data suggest that dysfunctional coronary microcirculation plays a pivotal role in the progression of heart failure despite an optimal therapy used. Therefore, we hypothesize that improvement in microvascular function by calcium antagonist, verapamil may result in additional clinical benefit. Thus, the aim of this study is to compare the effect of treatment with verapamil or carvedilol on long-term outcomes in stable, chronic heart failure secondary to non-ischemic cardiomyopathy.
Conditions
- Systolic Heart Failure
- Myocardial Disease
- Cardiomyopathy
Interventions
- DRUG
-
Verapamil
Sponsors & Collaborators
-
Medical University of Silesia
lead OTHER
Principal Investigators
-
Romuald Wojnicz, MD, PhD · Medical University of Silesia
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-01-31
- Completion
- 2007-12-31
Countries
- Poland
Study Locations
More Related Trials
-
Determination of Drug Levels for Pharmacotherapy of Heart Failure
NCT06035978 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
The Effect of Sacubitril/valsartan Versus Ramipril on Left Ventricular Function and Remodeling in Patients with Ischemic Heart Failure with Mid-range Ejection Fraction
NCT05508035 ·Status: RECRUITING ·Phase: PHASE3
-
The Bio-Clinical Effects of the (Sacubitril-Valsartan) Combination on Patients With Chronic Heart Failure
NCT04688294 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Carvedilol on Suppressing the Premature Ventricular Complex/Ventricular Tachycardia From Outflow Tract
NCT03587558 ·Status: UNKNOWN ·Phase: PHASE4
-
Is Sacubitril-valsartan Superior to Dapagliflozin in Improving Myocardial Function Performance
NCT06090487 ·Status: COMPLETED ·Phase: NA
-
Evaluation and Management of Cardio Toxicity in Oncologic Patients
NCT02818517 ·Status: RECRUITING
-
Effects of Sacubitril/Valsartan on Exercise Capacity, Natriuretic Peptides and Ventricular Remodeling in Heart Failure
NCT04434170 ·Status: COMPLETED
-
Real-world Research : Assessment of Effect of Combination of Drugs in the Treatment of Heart Failure
NCT06158711 ·Status: NOT_YET_RECRUITING
-
Safety of Repeat Doses of IV Serelaxin in Subjects With Chronic Heart Failure
NCT01982292 ·Status: COMPLETED ·Phase: PHASE2
-
Pulmonary REsistance Modification Under Treatment With Sacubitril/valsartaN in paTients With Heart Failure With Reduced Ejection Fraction
NCT05487261 ·Status: RECRUITING ·Phase: PHASE4
-
Prospective Monitoring of Angiotensin Receptor Neprilysin Inhibitor in Older Adults With Heart Failure and Frailty
NCT04743063 ·Status: UNKNOWN
-
A Safety Study Comparing Natrecor (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive Heart Failure
NCT00270400 ·Status: COMPLETED ·Phase: PHASE3
-
Carvedilol SR Study for Biomarkers From Blood and Urine and Safety of in Patients With Heart Failure With Preserved Ejection Fraction
NCT03948685 ·Status: UNKNOWN ·Phase: PHASE4
-
Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone
NCT00391846 ·Status: COMPLETED ·Phase: PHASE4
-
Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy
NCT05569382 ·Status: RECRUITING ·Phase: PHASE4
-
randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure
NCT02900378 ·Status: COMPLETED ·Phase: PHASE3
-
Immediate Release Versus Slow Release Carvedilol in Heart Failure
NCT03209180 ·Status: UNKNOWN ·Phase: PHASE4
-
Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure
NCT04498780 ·Status: COMPLETED
-
Role of Sacubitril/Valsartan in the Improvement of Heart Failure With Reduced Ejection Fraction
NCT04397302 ·Status: COMPLETED
-
Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction
NCT02874794 ·Status: COMPLETED ·Phase: PHASE4
-
Digoxin Versus Ivabradine in Heart Failure With Reduced Ejection Fraction
NCT02046044 ·Status: UNKNOWN ·Phase: PHASE4
-
A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.
NCT00270374 ·Status: COMPLETED ·Phase: PHASE3
-
Influence of Sacubitril/Valsartan on Autonomic Cardiac Nervous System in Heart Failure Patients: an Exploratory Study
NCT04587947 ·Status: COMPLETED ·Phase: NA
-
ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure
NCT05117736 ·Status: TERMINATED ·Phase: NA
-
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure
NCT00323037 ·Status: COMPLETED ·Phase: PHASE3