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Role of Sacubitril/Valsartan in the Improvement of Heart Failure With Reduced Ejection Fraction

NCT04397302 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 652

Last updated 2020-05-28

No results posted yet for this study

Summary

This prospective study evaluates the mechanisms of benefit of sacubitril/valsartan in a population of outpatients with heart failure with reduced ejection fraction, to investigate the relationship between the effects on left ventricular ejection fraction and volumes and noninvasively hemodynamic echo-derived parameters, as cardiac output and left ventricular filling pressure.

Conditions

  • Heart Failure, Left Sided
  • Left Ventricular Dysfunction
  • Ventricular Remodeling

Interventions

DIAGNOSTIC_TEST

Role of Sacubitril/Valsartan in Hemodynamic and Echocardiographic Improvement of Heart Failure With Reduced Ejection Fraction

Reverse Remodeling is Associated With Hemodynamic Improvement and Stabilization in Outpatients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan: an Echocardiographic Study

Sponsors & Collaborators

  • Università degli Studi di Brescia

    collaborator OTHER

  • Federico II University

    collaborator OTHER

  • Ospedali Riuniti di Foggia

    collaborator OTHER

  • University Of Perugia

    collaborator OTHER

  • Monaldi Hospital

    collaborator OTHER

  • University of Messina

    collaborator OTHER

  • University of Siena

    collaborator OTHER

  • University of Salerno

    collaborator OTHER

  • Fondazione IRCCS Policlinico San Matteo di Pavia

    collaborator OTHER

  • Azienda Ospedaliero-Universitaria di Parma

    collaborator OTHER

  • Azienda Unita Sanitaria Locale di Piacenza

    collaborator OTHER

  • Italian Society of Cardiology

    lead OTHER

Principal Investigators

  • Frank L Dini, MD · Italian Society of Cardiology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-13
Primary Completion
2020-03-16
Completion
2020-03-16

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04397302 on ClinicalTrials.gov