Exercise Training in Older Diabetic Women

Summary

Type 2 diabetics (non-insulin-dependent) are more than five times as likely to suffer an initial myocardial infarction (MI; heart attack) compared to nondiabetics.Female diabetics in particular, have a higher mortality rate for coronary artery disease (CAD) than male diabetics.C-reactive protein measurement in the clinical setting enhances the detection of individuals who are at high risk for cardiovascular disease (CVD), by providing additional predictive value.

We propose to study the effects of a supervised exercise and diet intervention on cardiovascular disease risk in postmenopausal diabetic women. We will recruit 35 postmenopausal, sedentary type 2 diabetics who will undergo a 3 month exercise and dietary intervention. They will exercise 3 times a week for 30 min in a supervised setting. Exercise mode will be aerobic and self-selected (i.e. treadmill, bike) at an intensity level of 50-85% VO2peak. Blood glucose will be monitored before and after exercise. The dietary intervention will consist of 6 meetings with a registered dietitian.

The study is designed to test the following hypotheses:

* Cardiovascular disease risk measures will be different following a 3-month exercise and diet intervention.

* H1: Blood markers for coronary artery disease risk, as measured by CRP, TC, LDL, TG, FG, fasting insulin, and HbA1c, will be different following a 3-month exercise and diet intervention.
* H2: Anthropometric measures of coronary artery disease risk, as measured by WHR, will be different following a 3-month exercise and diet intervention.
* H3: Resting blood pressure, as measured by SBP and DBP, will be different following a 3-month exercise and diet intervention.
* H4: Total body fat, as measured by DXA, will be different following a 3-month exercise and diet intervention.
* Health-related measures will be different following a 3-month exercise and diet intervention.

* H1: Cardiorespiratory fitness, as measured by maximal oxygen consumption (VO2max) will be different following a 3-month exercise and diet intervention.
* H2: Bone-mineral density, as measured by DXA, will be different following a 3-month exercise and diet intervention.
* H3: Dietary measures (total daily kcal, and daily fat kcal) will be different following a 3-month exercise and diet intervention.

Conditions

• Cardiovascular Diseases
• Diabetes Mellitus, Type 2

Interventions

BEHAVIORAL

3-month Exercise Training and Diet Education

Sponsors & Collaborators

• University of California, San Francisco

  collaborator OTHER

• University of San Francisco

  lead OTHER

Principal Investigators

• Deborah Sellmeyer, M.D. · University of California, San Francisco

Study Design

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

45 Years

Max Age

75 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2006-06-30

Completion

2007-05-31

Countries

• United States

Study Locations