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Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels

NCT00330980 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1000

Last updated 2014-03-20

No results posted yet for this study

Summary

Statins are cholesterol-lowering medications that are often prescribed for individuals with high cholesterol and who are at risk for heart disease. Preliminary research has shown that statins may have other effects on the body that are unrelated to the heart. The purpose of this study is to evaluate the impact of statins on mood, mental processes, aggression, and serotonin levels.

Conditions

  • Dyslipidemias

Interventions

DRUG

40 mg Pravastatin (Pravachol)

Participants will receive 40 mg of pravastatin for 6 months.

DRUG

20 mg Simvastatin

Participants will receive 20 mg of simvastatin for 6 months.

DRUG

Placebo

Participants will receive placebo for 6 months.

Sponsors & Collaborators

Principal Investigators

  • Beatrice A. Golomb, MD, PhD · University of California, San Diego

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2000-04-30
Primary Completion
2004-03-31
Completion
2004-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00330980 on ClinicalTrials.gov