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Treatment of Survivors After Botulism Outbreak

NCT00314080 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 18

Last updated 2008-10-24

No results posted yet for this study

Summary

Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9 high facility hospitals for treatment of severe respiratory failure and autonomic nervous system involvement. Among these patients, we aimed to assess the relationship between the rate of ventilator dependence and the occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of the botulism outbreak), as well as the relationship between ventilator dependence and negative inspiratory pressure.

Methods. The investigators reviewed the circumstances and timing of symptoms following exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals) with severe respiratory failure received a low- and high-rate repetitive nerve stimulation test, and negative inspiratory pressure was measured.

Conditions

Interventions

DRUG

Botulinum AntiToxin

PROCEDURE

neuro-electrophysiologic study, repetitive nerve stimulation

PROCEDURE

Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure

Sponsors & Collaborators

  • Rajavithi Biomolecular Research Center

    collaborator OTHER

  • Department of Medical Services Ministry of Public Health of Thailand

    lead OTHER_GOV

Principal Investigators

  • Subsai Kongsaengdao, M.D. · Department of Medical Services Ministry of Public Health of Thailand

Eligibility

Min Age
1 Year
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-03-31
Completion
2006-04-30

Countries

  • Thailand

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00314080 on ClinicalTrials.gov