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18F-Fluoride Positron Emission Tomography (PET) in Paget's Disease of Bone

NCT00306046 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2006-03-22

No results posted yet for this study

Summary

18 F-fluoride Positron emission tomography (PET) is able to demonstrate and quantify the metabolic activity locally in the skeleton (1). This technique should, therefore, also be able to demonstrate a dramatic decrease in the metabolic activity in localized monostotic Paget's disease lesions after therapy. In this condition, indeed, the usual biological markers may be unhelpful to assess the efficacy of therapy, because they are usually comprised in the normal range for single pagetic localizations, even before therapy (2). The main purpose of this trial is to assess the early and long term response of pagetic bone to bisphosphonate therapy.

Conditions

  • Paget's Disease of Bone

Interventions

DRUG

Bisphosphonate treatment

Sponsors & Collaborators

  • Fonds National de la Recherche Scientifique

    collaborator OTHER

  • Université Catholique de Louvain

    lead OTHER

Principal Investigators

  • Adrien T. NZEUSSEU, MD · Université Catholique de Louvain

  • Max LONNEUX, MD, PhD · Université Catholique de Louvain

  • Johanne INSTALLE, MD · Université Catholique de Louvain

  • Anne BOL, PhD · Université Catholique de Louvain

  • Geneviève DEPRESSEUX · Université Catholique de Louvain

  • Jean-Pierre DEVOGELAER, MD · Université Catholique de Louvain

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
0 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-02-28
Completion
2006-03-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00306046 on ClinicalTrials.gov