PXD101 in Treating Patients With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
NCT00303953 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 22
Last updated 2014-05-12
Summary
This phase II trial is studying how well PXD101 works in treating patients with relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. PXD101 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer.
Conditions
- Recurrent Adult Burkitt Lymphoma
- Recurrent Adult Diffuse Large Cell Lymphoma
Interventions
- DRUG
-
belinostat
Given IV
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Steven Bernstein · SWOG Cancer Research Network
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-01-31
- Primary Completion
- 2010-01-31
- Completion
- 2010-08-31
Countries
- United States
Study Locations
More Related Trials
-
A Phase Ib Study of Belinostat With RDHAP Chemotherapy (Dexamethasone, Cytarabine, Cisplatinum) in Adults With Relapsed or Refractory Diffuse Large B-cell Lymphoma
NCT02532192 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT03873025 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma
NCT03947255 ·Status: TERMINATED ·Phase: PHASE2
-
Phase I-II Study in CD30 Positive Diffuse Large B-cell Lymphoma Patients Refractory to First Line Chemotherapy or in First Relapse
NCT03356054 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Axicabtagene Ciloleucel in Participants With Relapsed/Refractory Indolent Non-Hodgkin Lymphoma
NCT03105336 ·Status: COMPLETED ·Phase: PHASE2
-
Oxaliplatin in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
NCT00006473 ·Status: COMPLETED ·Phase: PHASE2
-
Testing the Safety of the Anti-cancer Drugs Tazemetostat and Belinostat in Patients With Lymphomas That Have Resisted Treatment
NCT05627245 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Ixabepilone in Treating Patients With Relapsed or Refractory Lymphoproliferative Disorders
NCT00052572 ·Status: COMPLETED ·Phase: PHASE2
-
Pilot Study of Brentuximab Vedotin in Relapsed/Refractory Peripheral T-Cell Lymphoma Expressing CD30
NCT01841021 ·Status: TERMINATED ·Phase: NA
-
Tisagenlecleucel in Adult Patients With Aggressive B-cell Non-Hodgkin Lymphoma
NCT03570892 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Evaluate Efficacy and Safety of Oral Abexinostat in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)
NCT03936153 ·Status: RECRUITING ·Phase: PHASE2
-
Belinostat for Solid Tumors and Lymphomas in Patients With Varying Degrees of Hepatic Dysfunction
NCT01273155 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas
NCT03179930 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study to Evaluate an Oxaliplatin-based Chemotherapy in Patients With Resistant or Relapsing Non-Hodgkin Lymphoma.
NCT01019863 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase I Study of Romidepsin, Gemcitabine, Oxaliplatin, and Dexamethasone in Patients With Relapsed/Refractory Aggressive Lymphomas
NCT02181218 ·Status: COMPLETED ·Phase: PHASE1
-
Ixabepilone in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma
NCT00058019 ·Status: COMPLETED ·Phase: PHASE2
-
Ruxolitinib Phosphate to Treat Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma After Stem Cell Transplant
NCT01431209 ·Status: COMPLETED ·Phase: PHASE2
-
Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage
NCT00589290 ·Status: COMPLETED ·Phase: PHASE2
-
Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma
NCT05313243 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma
NCT07011056 ·Status: RECRUITING ·Phase: PHASE3
-
A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL
NCT05615636 ·Status: RECRUITING ·Phase: PHASE2
-
Belinostat in Relapsed or Refractory Peripheral T-Cell Lymphoma
NCT00865969 ·Status: COMPLETED ·Phase: PHASE2
-
To Evaluate Safety and Pharmacokinetics of Belinostat in Patients Who Have Mild, Moderate and Severe Renal Impairment.
NCT02679131 ·Status: TERMINATED ·Phase: PHASE1
-
Copanlisib Hydrochloride and Nivolumab in Treating Patients With Recurrent or Refractory Diffuse Large B-cell Lymphoma or Primary Mediastinal Large B-cell Lymphoma
NCT03484819 ·Status: COMPLETED ·Phase: PHASE2
-
Denileukin Diftitox in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
NCT00138164 ·Status: COMPLETED ·Phase: PHASE2