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Alteplase for Blood Flow Restoration in Hemodialysis Catheters

NCT00303420 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2008-12-19

No results posted yet for this study

Summary

We are investigating a new way of administering alteplase to remove clots from hemodialysis catheters. Currently, alteplase is left to dwell inside the catheter between dialysis treatments to dissolve the clot and restore blood flow through the catheter. We have developed a new way to administer alteplase by advancing it to the tip of the catheter at regular 10 minute intervals. We hypothesize that our new "push" protocol will dissolve clots in hemodialysis catheters better and faster than the current dwell method.

Conditions

Interventions

DRUG

Alteplase "push" protocol

alteplase 2 mg / lumen. Instill and wait 10 minutes, instill 0.3 ml normal saline, wait 10 minutes, instill 0.3 ml of normal saline, wait 10 minutes and aspirate.

DRUG

alteplase dwell arm

alteplase 2 mg / lumen. Instill and let it dwell for 30 minutes. Assess catheter and allow to dwell for a total of 2 hours if necessary

Sponsors & Collaborators

Principal Investigators

  • Lavern M Vercaigne, Pharm.D. · University of Manitoba

  • James M Zacharias, MD · University of Manitoba, Internal Medicine, Section of Nephrology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-09-30
Primary Completion
2008-12-31
Completion
2008-12-31

Countries

  • Canada

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00303420 on ClinicalTrials.gov