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Exercise And Rosuvastatin Treatment: Is There an Anti-Inflammatory Synergy?

NCT00295373 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2007-04-20

No results posted yet for this study

Summary

The purpose of this study is to determine whether the effects of rosuvastatin treatment and exercise training can be synergistic, with respect to the innate immune receptor TLR4, markers of systemic inflammation, and stimulated production of inflammatory cytokines, in hypercholesterolemic subjects. It is hypothesized that a rosuvastatin and exercise intervention will synergistically lower measured variables, so as to be anti-inflammatory.

Conditions

  • Nonfamilial Hypercholesterolemia
  • Physical Inactivity

Interventions

DRUG

Rosuvastatin

BEHAVIORAL

Exercise Training

Sponsors & Collaborators

  • Purdue University

    lead OTHER

Principal Investigators

  • Robert E Hannemann, MD · Purdue University

  • Michael G Flynn, PhD · Purdue University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-02-28
Completion
2007-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00295373 on ClinicalTrials.gov