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PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography

NCT00259441 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 320

Last updated 2007-07-12

No results posted yet for this study

Summary

The contrast induced kidney toxicity has been known to affect the mortality and morbidity in the patients undergoing coronary angiography. But the mechanism and therapeutic strategy for it is not well known. Nowadays, it is reported that the N-acetylcysteine may have preventive effects for contrast induced kidney toxicity with its antioxidant effects.The statins have been reported to have many other effects other than the lipid lowering effect-including antioxidant effect, so we hypothesized that the antioxidant effect of simvastatin may prevent the contrast induced kidney toxicity.

Conditions

Interventions

DRUG

Simvastatin

Sponsors & Collaborators

  • Seoul National University Hospital

    lead OTHER

Principal Investigators

  • Byung-Hee Oh, M.D., Ph.D. · Seoul National University Hospital, Department of Internal Medicine/ Cardiovascular Center

  • Hyo-Soo Kim, M.D.,Ph.D. · Seoul National University Hospital, Department of Internal Medicine/ Cardiovascular Center

  • Sang-Ho Jo, M.D. · Seoul National University Hospital, Department of Internal Medicine/ Cardiovascular Center

  • Bon-Kwon Koo, M.D.,Ph.D. · Seoul National University Hospital, Department of Internal Medicine/ Cardiovascular Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-02-28
Completion
2006-03-31

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00259441 on ClinicalTrials.gov