Sorafenib in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT00253578 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2013-01-07
Summary
This phase II trial is studying how well sorafenib works in treating patients with relapsed or refractory multiple myeloma. Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer
Conditions
- Refractory Multiple Myeloma
Interventions
- DRUG
-
sorafenib tosylate
Given PO
- OTHER
-
laboratory biomarker analysis
Correlative studies
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Mohamad Hussein · SWOG Cancer Research Network
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-03-31
- Primary Completion
- 2007-11-30
Countries
- United States
Study Locations
More Related Trials
-
Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
NCT00335764 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Temozolomide and Sorafenib in Treating Patients With Metastatic or Unresectable Melanoma
NCT00602576 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib in Treating Patients With Advanced Malignant Solid Tumors
NCT00810394 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib in Treating Patients With Advanced Anaplastic Thyroid Cancer
NCT00126568 ·Status: TERMINATED ·Phase: PHASE2
-
Sorafenib With Either Temsirolimus or Tipifarnib in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed By Surgery
NCT00281957 ·Status: COMPLETED ·Phase: PHASE2
-
S0505 Sorafenib in Treating Patients With Advanced Soft Tissue Sarcomas
NCT00217620 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib and Temsirolimus in Treating Patients With Metastatic, Recurrent, or Unresectable Melanoma
NCT00349206 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib Tosylate in Treating Patients With Locally Advanced, Metastatic, or Locally Recurrent Thyroid Cancer
NCT00095693 ·Status: TERMINATED ·Phase: PHASE2
-
Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma.
NCT00107432 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib Tosylate in Treating Younger Patients With Relapsed or Refractory Rhabdomyosarcoma, Wilms Tumor, Liver Cancer, or Thyroid Cancer
NCT01502410 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib in Treating Patients With Soft Tissue Sarcomas (Extremity Sarcoma Closed to Entry as of 5/30/07)
NCT00330421 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib and Bortezomib in Treating Patients With Advanced Cancer
NCT00303797 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib and Temozolomide in Treating Patients With Stage III or Stage IV Melanoma
NCT00811759 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Phase II Evaluation of FTase Inhibitor (FTI)in Treatment of Advanced Multiple Myeloma
NCT00012350 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer
NCT00390325 ·Status: COMPLETED ·Phase: PHASE2
-
Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia
NCT01159301 ·Status: TERMINATED ·Phase: PHASE1
-
Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma
NCT02599090 ·Status: WITHDRAWN ·Phase: PHASE2
-
Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors
NCT00131911 ·Status: COMPLETED ·Phase: PHASE2
-
Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma
NCT01303341 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis
NCT02066181 ·Status: COMPLETED ·Phase: PHASE3
-
Bevacizumab and Sorafenib in Treating Patients With Unresectable Stage III or Stage IV Malignant Melanoma
NCT00387751 ·Status: COMPLETED ·Phase: PHASE2
-
Tipifarnib and Sorafenib Tosylate in Treating Patients With Biopsiable Advanced Cancer
NCT00244972 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies
NCT02937675 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Clinical Study of TAB006 in Patients With Previously Treated, Advanced Malignancies
NCT05253105 ·Status: WITHDRAWN ·Phase: PHASE1
-
Sorafenib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Stage III Melanoma
NCT00492505 ·Status: UNKNOWN ·Phase: PHASE2