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MPAACS: Magnesium for the Prevention of Atrial Arrhythmias After Cardiac Surgery

NCT00250965 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 927

Last updated 2010-11-04

No results posted yet for this study

Summary

The objective of our research is to determine whether treatment with magnesium will reduce the incidence of atrial fibrillation in patients undergoing cardiac surgery. Several small studies of magnesium have already been conducted, but these studies were small and the results conflicting. A large, well-conducted study of magnesium treatment is required to definitively determine whether magnesium is effective in preventing this common complication after surgery. In addition, our study will include patients undergoing valvular surgery, a group previously excluded from research despite the fact that they are at increased risk of atrial fibrillation.

Conditions

Interventions

DRUG

intravenous magnesium

Subjects will be randomized prior to surgery (1:1) to receive 5 g magnesium or placebo (saline) bolus by the anaesthesiologist upon removal of the crossclamp. On postoperative days 1 through 4, subjects will receive either IV MgSO4 (5g in 250 ml normal saline) or IV placebo (250 ml normal saline) infusion over 4 hours daily.

Sponsors & Collaborators

  • Heart and Stroke Foundation of Canada

    collaborator OTHER

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Karin H Humphries, DSc · University of British Columbia/St. Paul's Hospital

  • Hubert Wong, PhD · University of British Columbia, Department of Health Care & Epidemiology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-07-31
Primary Completion
2008-09-30
Completion
2009-02-28

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00250965 on ClinicalTrials.gov