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Assessment of Inflammatory Mediators (AIM)

NCT00219895 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2007-12-25

No results posted yet for this study

Summary

Specific Aim: To determine whether neutrophils, active elastase, and cytokines measured in sputum induced using hypertonic saline are useful screening tests for determining if a particular agent with known anti-inflammatory properties is a suitable candidate for more extensive clinical trials in patients with CF. This aim will be addressed using an anti-inflammatory agent, ibuprofen, that has been shown to have clinical benefit in CF. A "no treatment" arm will be included as the control group.

Conditions

Interventions

DRUG

Ibuprofen

Sponsors & Collaborators

  • Cystic Fibrosis Foundation

    collaborator OTHER

  • Ramsey, Bonnie, MD

    lead INDIV

Principal Investigators

  • James Chmiel, MD, MPH · Case Western Reserve University - Rainbow Babies and Children's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-08-31
Completion
2006-03-31

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00219895 on ClinicalTrials.gov