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Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone

NCT00218608 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 158

Last updated 2012-01-31

No results posted yet for this study

Summary

Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect. Cocaine users are at risk for many health problems, both directly and indirectly related to the effects of cocaine. Disulfiram, a drug used to treat chronic alcoholism, may be effective in reducing cocaine use. This study will evaluate the effectiveness of three different doses of disulfiram in treating cocaine dependence in opioid- and cocaine-dependent individuals maintained on methadone.

Conditions

  • Cocaine-Related Disorders
  • Opioid-Related Disorders

Interventions

DRUG

Disulfiram

Disulfiram at 0, 62.5, 125 and 250 mg/day were administered during weeks 3-14

Sponsors & Collaborators

  • Yale University

    collaborator OTHER

  • University of Arkansas

    lead OTHER

Principal Investigators

  • Alison Oliveto, PhD · UAMS

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2001-04-30
Primary Completion
2007-01-31
Completion
2007-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00218608 on ClinicalTrials.gov