German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)

Summary

The study evaluates the efficacy and tolerability of a risk- and subtype-adapted chemotherapy over one year, followed by randomized either intensified or conventional maintenance therapy. It includes a distinct protocol for the subgroup 'mature B-ALL',

Conditions

• Adult Acute Lymphocytic Leukemia

Interventions

DRUG

Asparaginase

DRUG

Vincristine

DRUG

Daunorubicin, Adriamycin

DRUG

Cyclophosphamide

DRUG

Ifosfamide

DRUG

Cytarabine

DRUG

Mitoxantrone

DRUG

Methotrexate

DRUG

6-Mercaptopurine

DRUG

6-Thioguanine

DRUG

VM26

DRUG

Dexamethasone / Prednisolone

PROCEDURE

CNS Irradiation

PROCEDURE

Mediastinal Irradiation

PROCEDURE

Stem Cell Transplantation

Sponsors & Collaborators

• Deutsche Krebshilfe e.V., Bonn (Germany)

  collaborator OTHER

• Goethe University

  lead OTHER

Principal Investigators

• Dieter Hoelzer, MD, PhD · University of Frankfurt, Medical Department II

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

15 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1993-04-30

Primary Completion

1999-01-31

Completion

2001-05-31

Countries

• Germany

Study Locations