Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes
NCT00171912 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 38
Last updated 2017-02-23
Summary
This trial is for various types of malignancies which may depend on certain enzymes (tyrosine kinases) for growth. The objective of this study is to assess to what extent imatinib mesylate blocks these enzymes and to assess the effect on the malignancy.
Conditions
- Hypereosinophilic Syndrome
- Systemic Mastocytosis
- Chronic Myelomonocytic Leukemia
- Dermatofibrosarcoma
Interventions
- DRUG
-
imatinib mesylate
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Novartis Pharmeceuticals
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 16 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2004-09-30
- Primary Completion
- 2012-01-31
- Completion
- 2012-01-31
Countries
- Australia
Study Locations
More Related Trials
-
Imatinib Mesylate in Treating Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumor
NCT00685828 ·Status: UNKNOWN ·Phase: PHASE3
-
Imatinib Mesylate After Irinotecan and Cisplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer
NCT00248482 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator
NCT01742299 ·Status: COMPLETED ·Phase: PHASE4
-
STI571 in Treating Patients With Recurrent Leukemia
NCT00004932 ·Status: COMPLETED ·Phase: PHASE1
-
Oblimersen and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia
NCT00049192 ·Status: COMPLETED ·Phase: PHASE2
-
Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma
NCT00031915 ·Status: COMPLETED ·Phase: PHASE2
-
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction
NCT00025415 ·Status: COMPLETED ·Phase: PHASE1
-
Imatinib Mesylate and Capecitabine in Treating Patients With Advanced Solid Tumors
NCT00253565 ·Status: COMPLETED ·Phase: PHASE1
-
Imatinib Mesylate in Treating Patients With Locally Recurrent or Metastatic Dermatofibrosarcoma Protuberans
NCT00084630 ·Status: COMPLETED ·Phase: PHASE2
-
Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditions
NCT02103322 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Study of Hyper-CVAD Plus Imatinib Mesylate for Philadelphia-Positive Acute Lymphocytic Leukemia
NCT00038610 ·Status: COMPLETED ·Phase: PHASE2
-
Investigating Intracellular and Plasma Imatinib Levels in Chronic Myeloid Leukemia
NCT00947830 ·Status: COMPLETED
-
Imatinib Mesylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Who Have Received Chemotherapy
NCT00509093 ·Status: COMPLETED ·Phase: PHASE2
-
Imatinib Mesylate and Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
NCT00045604 ·Status: COMPLETED ·Phase: PHASE1
-
Imatinib and Trametinib for KRAS-mutated Solid Tumor
NCT06962254 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)
NCT01751919 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemia
NCT02317159 ·Status: UNKNOWN ·Phase: PHASE4
-
Imatinib Standard Dose (400 mg/Day) Versus Imatinib High Dose (800 mg/Day)
NCT00514488 ·Status: COMPLETED ·Phase: PHASE3
-
Imatinib Mesylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
NCT00470470 ·Status: COMPLETED ·Phase: PHASE2
-
Ipilimumab and Imatinib Mesylate in Advanced Cancer
NCT01738139 ·Status: COMPLETED ·Phase: PHASE1
-
Imatinib Mesylate in Treating Patients With Refractory or Relapsed Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer, or Ovarian Low Malignant Potential Tumor
NCT00039585 ·Status: COMPLETED ·Phase: PHASE2
-
Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia
NCT00054431 ·Status: COMPLETED ·Phase: PHASE2
-
Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib Mesylate
NCT00038675 ·Status: COMPLETED ·Phase: NA
-
Arsenic Trioxide and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia
NCT00053248 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
S0338, Imatinib Mesylate and Capecitabine in Treating Women With Progressive Stage IV Breast Cancer
NCT00087152 ·Status: COMPLETED ·Phase: PHASE2