MedTrace Logo

Genetic Risk for Attention Deficit Hyperactivity Disorder Expressed in Brain Functioning

NCT00143832 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2007-03-20

No results posted yet for this study

Summary

Poor inhibitory control has been proposed to be central to the cognitive deficits and symptomatology associated with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a highly heritable disorder with an increased incidence among the siblings of affected individuals. In the current proposal we investigate the expression of genetic susceptibility for ADHD in brain functioning. We will study cognitive functioning in patients with ADHD, their unaffected siblings and healthy matched controls. Our aims are 1) to determine whether increased familial risk for ADHD is associated with differential patterns of brain activation compared to normally developing children, during the performance of tasks designed to probe cognitive functions that are compromised in ADHD and 2) to determine whether differential patterns of activation are similar for boys with ADHD and their unaffected siblings.

Conditions

  • Attention Deficit Hyperactivity Disorder

Sponsors & Collaborators

  • Netherlands Organisation for Scientific Research

    collaborator OTHER_GOV

  • UMC Utrecht

    lead OTHER

Principal Investigators

  • Sarah Durston, Ph.D. · RMI of Neuroscience, UMC Utrecht

  • Herman van Engeland, M.D. Ph.D. · RMI of Neuroscience, UMC Utrecht

Eligibility

Min Age
8 Years
Max Age
20 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-09-30

Countries

  • Netherlands

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00143832 on ClinicalTrials.gov