MedTrace Logo

Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine

NCT00124072 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 12064

Last updated 2012-02-01

Study results available
· View outcomes & findings →

Summary

SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen using 80 mg simvastatin daily produces a larger and worthwhile reduction in cardiovascular events compared with a standard 20 mg daily regimen and whether reducing blood homocysteine levels with a daily dose of folic acid 2 mg + vitamin B12 1 mg compared with matching placebo produces a worthwhile reduction in vascular disease.

Conditions

Interventions

DRUG

Simvastatin 20 mg daily

Simvastatin 20 mg tablet once daily

DIETARY_SUPPLEMENT

Folic acid 2 mg + vitamin B12 1 mg daily

Folic acid 2 mg + vitamin B12 1 mg tablet once daily

DRUG

Simvastatin 80 mg daily

Simvastatin 80 mg tablet once daily

DRUG

Placebo

Placebo vitamin B12/folic acid tablet once daily

Sponsors & Collaborators

Principal Investigators

  • Rory Collins, MB BS FRCP · University of Oxford

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1998-07-31
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00124072 on ClinicalTrials.gov