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Brain Plasticity of Verbal Memory in the Blind

NCT00059189 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 85

Last updated 2008-03-04

No results posted yet for this study

Summary

This study will examine whether blind people develop changes in the brain that improve memory function. Previous studies have shown that blind people, on average, perform better in memory tasks than sighted people. A possible reason for this is that parts of the brain that process visual information in sighted individuals are engaged in processing mnemonic (remembering) information in blind people.

Blind and sighted people 18 years of age and older are eligible for this study. Healthy, sighted individuals may participate in Part 1 of the study, which is designed to find appropriate words to use in tests for Part 2 of the study. Part 2 will include sighted people and blind people. It will examine whether the (visual) brain in blind people is processing mnemonic information in a way that helps with day-to-day memory functions. Blind participants in this study must have lost their sight by age 4. Candidates will be screened with a medical interview and examination and a brief test of short-term and long-term verbal memory. Sighted patients will also be tested for visual memory and for handedness.

Part 1 - Word Recognition Testing (2 sessions)

* Session 1: Participants listen to a number of words over a loudspeaker and try to remember them for a memory test that will be given 30 minutes later. For the test, subjects listen to words again and press one of three buttons as quickly as possible after hearing the word. The buttons signal whether the subject does or does not recognize the word with a 1) high level of confidence or 2) low level of confidence.
* Session 2: Participants hear a noun over a loudspeaker and have to find an appropriate verb for it, such as the verb (read) for the noun (book).

Part 2 - MRI Scanning and TMS Experiments (5 - 7 sessions)

* Magnetic resonance imaging (MRI): Participants perform the same procedures as described above for Part 1 while undergoing MRI of the brain. For this test, the subject lies on a table inside the MRI scanner - a narrow cylindrical tube with a strong magnetic field. Scanning time varies from 20 minutes to 3 hours, with most scans lasting between 45 and 90 minutes. (Earphones are used to hear the words for this test instead of a loudspeaker.)
* Transcranial magnetic stimulation (TMS): Participants undergo TMS while performing the same procedures described for Part 1. For TMS, a wire coil is held over the scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. Subjects may hear a click and feel a pulling sensation on the skin under the coil. There may be a twitch in muscles of the arm or leg. During the TMS, electrical muscle activity is recorded through the electrodes with a computer or other recording device. Each session lasts a maximum of 3 hours.

Conditions

Interventions

DEVICE

Magstim Rapid Magnetic Stimulator

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    lead NIH

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-04-30
Completion
2005-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00059189 on ClinicalTrials.gov