Therapeutic HIV Vaccine and Interleukin-2 to Increase the Immune System's Response to HIV
NCT00056797 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 92
Last updated 2016-12-14
Summary
This study will evaluate whether the HIV vaccine ALVAC vCP1452 given in combination with interleukin-2 (IL-2), also known as aldesleukin, can increase immune system function in people with HIV infection.
Conditions
- HIV Infections
Interventions
- BIOLOGICAL
-
ALVAC HIV vaccine (vCP1452)
- DRUG
-
Interleukin-2
Sponsors & Collaborators
-
National Institute of Allergy and Infectious Diseases (NIAID)
lead NIH
Principal Investigators
-
Kendall A. Smith, MD · Weill Medical College of Cornell University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- FACTORIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2002-03-31
- Primary Completion
- 2006-03-31
- Completion
- 2006-03-31
Countries
- United States
Study Locations
More Related Trials
-
A Study of the Safety and Effectiveness of an HIV Vaccine for HIV-Positive Patients Receiving Anti-HIV Drugs for at Least 2 Years
NCT00006509 ·Status: COMPLETED ·Phase: PHASE1
-
An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy
NCT00004978 ·Status: COMPLETED ·Phase: PHASE3
-
Interleukin-2 (IL-2) Treatment for HIV Infected Patients Who Have Interrupted Their Anti-HIV Drug Therapy
NCT00038259 ·Status: COMPLETED ·Phase: NA
-
Effectiveness of Adding Interleukin-2 to Anti-HIV Drugs in Patients Recently Infected With HIV
NCT00006441 ·Status: COMPLETED ·Phase: NA
-
Effect of Interleukin-2 on HIV Treatment Interruption
NCT00015704 ·Status: COMPLETED ·Phase: NA
-
Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients With CD4 T-Lymphocyte Count Greater Than 500 Cells/mm3 Who Received Antiretroviral Tx
NCT00071890 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine (ALVAC-HIV vCP1452) Use and Intermittent Withdrawal of Anti-HIV Drugs in Patients With HIV
NCT00011011 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load
NCT00013663 ·Status: COMPLETED ·Phase: PHASE2
-
Pharmacodynamics of Intermittent IL-2 Infusions in HIV Seropositive Patients
NCT00001474 ·Status: COMPLETED ·Phase: PHASE2
-
Subcutaneously Administered Interleukin-2 Therapy in HIV-Infected Patients
NCT00001357 ·Status: COMPLETED ·Phase: PHASE2
-
Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3
NCT00000948 ·Status: COMPLETED ·Phase: PHASE2
-
The Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3
NCT00000825 ·Status: COMPLETED ·Phase: PHASE2
-
Safety of the Candidate Vaccine C4-V3 Alone or With Interleukin-12 (IL-12) in HIV-Infected Patients Receiving Effective Anti-HIV Drug Therapy
NCT00005779 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy of Using Interleukin-2 in Antiretroviral Naïve HIV Patients (ANRS119)
NCT00120185 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Intermittent Aldesleukin Treatment With or Without Anti-HIV Drugs in HIV Infected People
NCT00110812 ·Status: COMPLETED ·Phase: PHASE2
-
HIV Immune and Virological Responses Following the Administration of IL-2 Either Alone or Combined to ALVAC-HIV 1433 and HIV Lipopeptides in Patients Treated Early With HAART During Primary Infection
NCT00196651 ·Status: TERMINATED ·Phase: PHASE2
-
Treatment With Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328
NCT00000923 ·Status: COMPLETED ·Phase: NA
-
A Study to Test the Safety of Recombinant Interleukin-2 (rIL-2) in HIV-Infected Children
NCT00000849 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Effectiveness of L2-7001 (Interleukin-2) in HIV-Positive Patients Receiving Anti-HIV Therapy
NCT00002449 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study to Evaluate the Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3
NCT00000889 ·Status: COMPLETED ·Phase: PHASE2
-
Immune Responses in HIV-Positive Patients Receiving an Anti-HIV Drug Combination When Given the HIV Vaccines Remune and vCP1452
NCT00006495 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC
NCT00000680 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I/II Study of the Combination of Azidothymidine and Interleukin-2 (IL-2) in the Treatment of HIV-Infected Patients
NCT00001282 ·Status: COMPLETED ·Phase: PHASE2
-
Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study)
NCT00013611 ·Status: COMPLETED ·Phase: PHASE3
-
Immunomodulation of HIV-1 Infected Individuals With PEG-Interleukin-2
NCT00002017 ·Status: COMPLETED ·Phase: NA