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Optimizing Electroconvulsive Therapy for Depression

NCT00045916 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 340

Last updated 2013-08-13

No results posted yet for this study

Summary

This study will evaluate the effectiveness of electroconvulsive therapy (ECT) administered with medication for the treatment of a major depressive episode (unipolar or bipolar) and will compare two types of ECT.

Conditions

Interventions

PROCEDURE

High dosage electroconvulsive therapy

Participants will receive high dosage right unilateral ECT at six times the seizure threshold.

DRUG

Nortriptyline

Participants will receive nortriptyline.

DRUG

Venlafaxine

Participants will receive venlafaxine.

DRUG

Lithium

Participants will receive lithium.

PROCEDURE

Low dosage electroconvulsive therapy

Participants will receive low dosage bilateral ECT at one and a half times the seizure threshold.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • New York State Psychiatric Institute

    lead OTHER

Principal Investigators

  • Harold A. Sackeim, PhD · New York State Psychiatric Institute and Columbia University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-02-28
Primary Completion
2006-12-31
Completion
2006-12-31

Countries

  • United States

Study Locations

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Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00045916 on ClinicalTrials.gov