Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia

Summary

This study will develop a national cord blood bank for siblings of patients with hemoglobinopathies and thalassemia.

Conditions

• Hematologic Diseases
• Anemia, Sickle Cell
• Beta-Thalassemia
• Hematopoietic Stem Cell Transplantation

Interventions

DRUG

Sangstat

DRUG

Cyclophosphamide

DRUG

Busulfan

DRUG

Mycophenolate Mofetil

DRUG

Cyclosporine

PROCEDURE

Cord Blood Transplantation

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  lead NIH

Principal Investigators

• Victor Aquino · University of Texas Southwestern Medical Center - Dallas

• Nancy Bunin · Children's Hospital of Philadelphia

• Martin Champagne · Hopital Ste-Justine

• Joel Brochstein · Hackensack Meridian Health

• Michael Joyce · Nemours Children's Clinic

• Naynesh Kamani · Children's National Research Institute

• Gary Kleiner · University of Miami Batchelor Children's Research Center

• Joanne Kurtzberg · Duke University Medical Center Children's Hospital

• Bertram H. Lubin · UCSF Benioff Children's Hospital Oakland

• Alexis Thompson · Ann & Robert H Lurie Children's Hospital of Chicago

• Donna Wall · Texas Transplant Institute

• Mark Walters · UCSF Benioff Children's Hospital Oakland

• Lolie Yu · Louisiana State University Children's Medical Center

Study Design

Purpose

TREATMENT

Eligibility

Min Age

3 Years

Max Age

14 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1999-01-31

Primary Completion

2006-08-31

Completion

2006-08-31

Countries

• United States
• Canada

Study Locations