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A Comparison of Two Ways to Manage Anti-HIV Treatment (The SMART Study)

NCT00027352 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 6000

Last updated 2009-11-25

No results posted yet for this study

Summary

The purpose of this study is to compare two ways of using anti-HIV drugs to help health care providers and patients decide how to best use anti-HIV treatments over many years. Many health care providers now treat patients with daily drugs to keep the viral load as low as possible. This approach helps patients with CD4 counts less than 200-250 cells/mm3 live longer without serious diseases. But it is not known if this is the best way to treat patients with higher CD4 counts. There is information suggesting that these patients may be able to wait to use anti-HIV drugs while CD4 counts are above 250 cells/mm3. Because this study will be carried out over several years, it will provide information on the long-term advantages and disadvantages of these two treatment strategies.

Conditions

  • HIV Infections

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Wafaa El-Sadr, MD, MPH · Harlem AIDS Treatment Group, Harlem Hospital Center

  • James Neaton, PhD · CPCRA Statistcal and Data Management Center / CCBR

Eligibility

Min Age
13 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Countries

  • United States
  • Argentina
  • Australia
  • Austria
  • Belgium
  • Brazil
  • Canada
  • Estonia
  • France
  • Germany
  • Ireland
  • Israel
  • Italy
  • Japan
  • Lithuania
  • Luxembourg
  • Martinique
  • New Zealand
  • Norway
  • Peru
  • Poland
  • Puerto Rico
  • Spain
  • Switzerland
  • Thailand
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00027352 on ClinicalTrials.gov