Gefitinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer
NCT00024089 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2013-02-11
Summary
Phase II trial to study the effectiveness of gefitinib in treating patients who have recurrent and/or metastatic head and neck cancer. Biological therapies such as gefitinib may interfere with the growth of tumor cells by blocking an enzyme necessary for cell growth.
Conditions
Interventions
- DRUG
-
gefitinib
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Richard H. Wheeler, MD · University of Utah
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2001-07-31
- Primary Completion
- 2006-03-31
Countries
- United States
Study Locations
More Related Trials
-
Chemotherapy Plus Gefitinib Followed by Chemotherapy, Radiation Therapy, and Gefitinib For Head and Neck Cancer
NCT00193284 ·Status: COMPLETED ·Phase: PHASE2
-
Gefitinib in Treating Patients Who Are Undergoing Surgery and/or Radiation Therapy for Locally Advanced or Recurrent Squamous Cell Skin Cancer
NCT00126555 ·Status: COMPLETED ·Phase: PHASE2
-
Cisplatin and ZD1839 + Re-Irradiation in Recurrent Squamous Cell Cancer of the Head and Neck
NCT00185835 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Iressa With/Without Concurrent Chemoradiotherapy on Tumor Gene Expression Profiles in Patients With Advanced Non-Nasopharyngeal Head and Neck Carcinoma
NCT00228488 ·Status: COMPLETED ·Phase: PHASE2
-
IRESSA™ (Gefitinib) With Cisplatin Plus Radiotherapy for the Treatment of Previously Untreated Unresected Late Stage III/IV Non-Metastatic Head and Neck Squamous Cell Carcinoma
NCT00229723 ·Status: COMPLETED ·Phase: PHASE2
-
Head and Neck Phase III Iressa Versus Methotrexate Refractory: Iressa Versus Methotrexate (IMEX)
NCT00206219 ·Status: COMPLETED ·Phase: PHASE3
-
Phase II Study of Skin Toxicity Dosing of IRESSA (Gefitinib) in Squamous Cell Carcinoma of the Head and Neck
NCT00519077 ·Status: COMPLETED ·Phase: PHASE2
-
Cisplatin, Fluorouracil, Iressa, and Radiation Therapy Patients With Locally Advanced Head and Neck Cancer
NCT00352105 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell Carcinoma of the Head and Neck
NCT00233636 ·Status: WITHDRAWN ·Phase: PHASE2
-
IRESSA in Combination With Cisplatin & Radiotherapy in Patients With Advanced Head & Neck Carcinoma
NCT00242749 ·Status: COMPLETED ·Phase: PHASE2
-
ZD1839 (IRESSA™) in Combination With Docetaxel & Cisplatin in Subjects With Metastatic Head & Neck Cancer
NCT00242762 ·Status: COMPLETED ·Phase: PHASE2
-
The IRESSA Novel Head and Neck Chemotherapy Evaluation Study
NCT00255476 ·Status: COMPLETED ·Phase: PHASE2
-
Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer
NCT00033449 ·Status: TERMINATED ·Phase: PHASE1
-
Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer
NCT01185171 ·Status: COMPLETED ·Phase: PHASE2
-
Safety Trial of IRESSA, Cisplatin and Radiation Therapy for Patients With Head and Neck Cancer
NCT00195078 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer
NCT00068497 ·Status: COMPLETED ·Phase: NA
-
Gefitinib, Paclitaxel, and Radiation Therapy in Treating Patients With Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck
NCT00083057 ·Status: COMPLETED ·Phase: PHASE1
-
Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC
NCT05057247 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Sorafenib/Cetuximab in Head and Neck Cancer
NCT00815295 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Gene Therapy in Treating Patients With Advanced Head and Neck Cancer
NCT00009841 ·Status: COMPLETED ·Phase: PHASE1
-
Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Recurrent/Metastatic HNSCC
NCT04313504 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Trial of HM781-36B in Patients With Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) After Failure of or Unfit for Platinum-containing Therapy
NCT02216916 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab
NCT00939627 ·Status: COMPLETED ·Phase: PHASE2
-
S9902 Docetaxel Plus Carboplatin in Treating Patients With Metastatic or Recurrent Head and Neck Cancer
NCT00003908 ·Status: COMPLETED ·Phase: PHASE2
-
Ribociclib and Spartalizumab in R/M HNSCC
NCT04213404 ·Status: UNKNOWN ·Phase: PHASE1