Interleukin-2 Plus Activated White Blood Cells in Treating Patients With Cancer That Has Not Responded to Chemotherapy or Radiation Therapy
NCT00019357 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2015-04-29
Summary
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill tumor cells. Combining white blood cells, which have been activated by a vaccine, with interleukin-2 may kill more cancer cells.
PURPOSE: Phase I trial to study the effectiveness of interleukin-2 plus activated white blood cells in treating patients with cancer that has not responded to chemotherapy or radiation therapy.
Conditions
- Unspecified Adult Solid Tumor, Protocol Specific
Interventions
- BIOLOGICAL
-
aldesleukin
- BIOLOGICAL
-
therapeutic autologous lymphocytes
- BIOLOGICAL
-
therapeutic tumor infiltrating lymphocytes
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Samir N. Khleif, MD · National Cancer Institute (NCI)
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1998-06-30
Countries
- United States
Study Locations
More Related Trials
-
Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors
NCT00019331 ·Status: COMPLETED ·Phase: PHASE2
-
Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors
NCT00003107 ·Status: COMPLETED ·Phase: PHASE1
-
Interleukin-2 in Treating Patients With Metastatic Kidney Cancer
NCT00018941 ·Status: COMPLETED ·Phase: PHASE3
-
Vaccine Therapy With or Without Interleukin-2 After Chemotherapy and an Autologous White Blood Cell Infusion in Treating Patients With Metastatic Melanoma
NCT00303836 ·Status: TERMINATED ·Phase: PHASE2
-
Cytotoxic T Cells and Interleukin-2 in Treating Adult Patients With Recurrent Brain Tumors
NCT00002572 ·Status: COMPLETED ·Phase: PHASE1
-
Interleukin-2 in Treating Patients With Metastatic Melanoma
NCT00002845 ·Status: UNKNOWN ·Phase: PHASE2
-
Vaccine Therapy, Interleukin-2, and Sargramostim in Treating Patients With Advanced Tumors
NCT00003125 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine Plus Interleukin-2 in Treating Patients With Advanced Melanoma
NCT00005949 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma That Has Not Responded to Previous Treatment
NCT00022438 ·Status: COMPLETED ·Phase: PHASE2
-
High-Dose Intravenous Interleukin-2 in Treating Patients With Metastatic Renal Cell Carcinoma (Kidney Cancer) That Has Not Responded to Previous Low-Dose Intravenous or Subcutaneous Interleukin-2
NCT00080977 ·Status: UNKNOWN ·Phase: PHASE2
-
Gene Therapy and Biological Therapy in Treating Patients With Ovarian Epithelial Cancer
NCT00019136 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma
NCT00019214 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Interleukin-12 in Treating Patients With Advanced Cancer
NCT00003330 ·Status: COMPLETED ·Phase: PHASE1
-
Biological Therapy in Previously Treated Patients With Non-small Cell Lung Cancer
NCT00003090 ·Status: UNKNOWN ·Phase: PHASE2
-
Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer
NCT00002504 ·Status: COMPLETED ·Phase: PHASE2
-
Interleukin-12 in Treating Patients With Metastatic or Recurrent Breast Cancer
NCT00004893 ·Status: COMPLETED ·Phase: PHASE2
-
Biological Therapy in Treating Patients With Metastatic Melanoma
NCT00045149 ·Status: COMPLETED ·Phase: PHASE1
-
Interleukin-2 and Sargramostim After Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma
NCT00085579 ·Status: WITHDRAWN ·Phase: PHASE2
-
Interleukin-2 Plus Monoclonal Antibody Therapy in Treating Patients With Solid Tumors
NCT00002994 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Therapy of Interleukin-12 and Interleukin-2 to Treat Advanced Cancer
NCT00005655 ·Status: TERMINATED ·Phase: PHASE1
-
Interleukin-12 Followed by Interferon Alfa in Treating Patients With Advanced Cancer
NCT00003451 ·Status: COMPLETED ·Phase: PHASE1
-
Relationship Between Natural Killer Cells' Ability to Kill Leukemia Cells and the Outcome of Patients With Acute Myeloid Leukemia Previously Treated With Interleukin-2
NCT00896701 ·Status: COMPLETED
-
Interleukin-2 in Treating Patients With Myelodysplastic Syndrome
NCT00002746 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer
NCT00019591 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Lymphocyte Re-infusion During Immune Suppression to Treat Metastatic Melanoma
NCT00001832 ·Status: COMPLETED ·Phase: PHASE2