Radiation Therapy With or Without Epoetin Alfa in Treating Patients With Head and Neck Cancer

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Epoetin alfa may help prevent or treat cancer-related anemia. It is not yet known whether radiation therapy is more effective with or without epoetin alfa in treating head and neck cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without epoetin alfa in treating patients who have head and neck cancer.

Conditions

• Head and Neck Cancer

Interventions

BIOLOGICAL

epoetin alfa

RADIATION

radiation therapy

Sponsors & Collaborators

• Trans Tasman Radiation Oncology Group

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Groupe Oncologie Radiotherapie Tete et Cou

  collaborator OTHER

• Radius Hungaricus Oncology Group

  collaborator OTHER

• Grup per l'Estudi dels Limfomes de Catalunya i Balears

  collaborator OTHER

• European Organisation for Research and Treatment of Cancer - EORTC

  lead NETWORK

Principal Investigators

• Philippe Lambin, MD · Maastricht University Medical Center

• Jacques Bernier, MD, PhD · Istituto Oncologico della Svizzera Italiana - Ospedale San Giovanni

• Jim Denham, MD · Newcastle Mater Misericordiae Hospital

• Volker G. Budach, MD, PhD · Charite University, Berlin, Germany

• Jean-Henri Bourhis, MD, PhD · Gustave Roussy, Cancer Campus, Grand Paris

• Ferenc Kaldau, MD · Radius Hungaricus Oncology Group

• Anna Sureda · Hospital de la Santa Cruz i Sant Pau

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2001-03-31

Primary Completion

2003-04-30

Countries

• Australia
• Belgium
• France
• Germany
• Hungary
• Israel
• Netherlands
• Spain
• Switzerland
• United Kingdom

Study Locations