Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
NCT00006060 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100
Last updated 2009-03-12
Summary
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization transfer ratio histogram parameters, and correlate these measurements with clinical measures of disability in patients with multiple sclerosis.
II. Measure the quantity of whole brain N-acetylaspartate in patients with multiple sclerosis and compare these values to those from age matched controls.
III. Determine the correlation between specific neuropsychological tests which assess global cognitive functioning and the quantitative measurements taken in these patients in this study.
Conditions
Interventions
- DRUG
-
standard gadolinium contrast
Sponsors & Collaborators
- collaborator OTHER
-
National Center for Research Resources (NCRR)
lead NIH
Principal Investigators
-
Robert I. Grossman, MD · New York University
Eligibility
- Min Age
- 20 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 1999-04-30
Countries
- United States
Study Locations
More Related Trials
-
Single Test to ARrive at MS Diagnosis. Using a Single MRI Brain Scan to Help Diagnose Multiple Sclerosis
NCT02485223 ·Status: UNKNOWN
-
Understanding Magnetic Resonance Imaging in Multiple Sclerosis
NCT03872583 ·Status: COMPLETED ·Phase: NA
-
An Examination of Cognitive Fatigue Using Functional Neuroimaging
NCT04885894 ·Status: RECRUITING
-
Application of Multiparametric Structural and Functional MRI in Unraveling the Substrates of Cognitive Impairment and Disability in Multiple Sclerosis
NCT06653283 ·Status: NOT_YET_RECRUITING
-
Measuring Silent Disease Progression in Multiple Sclerosis With a Multimodal Approach
NCT06501950 ·Status: RECRUITING
-
Regional Cortical Cerebral Quantitative MRI Perfusion Correlation Neurocognition in Multiple Sclerosis
NCT00812474 ·Status: COMPLETED
-
Evaluation of the Reproducibility of the Measurement of the QSM Signal (Quantitative Susceptibility Mapping)
NCT04465448 ·Status: TERMINATED
-
Serum Neurofilament Light in Multiple Sclerosis
NCT06282081 ·Status: ACTIVE_NOT_RECRUITING
-
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
NCT05491031 ·Status: RECRUITING ·Phase: NA
-
TMP001 in Relapsing-remitting Multiple Sclerosis
NCT02686788 ·Status: COMPLETED ·Phase: PHASE2
-
Study of the Safety and Efficacy of MLN1202 in Patients in Multiple Sclerosis
NCT01199640 ·Status: COMPLETED ·Phase: PHASE2
-
Multimodal Exploration of Patients With Multiple Sclerosis for an Early Detection of Subtle Progression
NCT05941975 ·Status: RECRUITING ·Phase: NA
-
Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
NCT02994121 ·Status: RECRUITING
-
Evaluation of the Impact of Lesions of the Motor and Proprioceptive Brain and Pan-medullary Pathways on Their Clinically and Electrophysiologically Assessed Function in Multiple Sclerosis
NCT04220814 ·Status: COMPLETED ·Phase: NA
-
Characterization of Cortical Injury in Early MS Patients: a 7T MRI Study
NCT03624296 ·Status: UNKNOWN ·Phase: NA
-
Risk Factors in Early Multiple Sclerosis
NCT03586986 ·Status: UNKNOWN
-
Ultra-high-field Brain MRI in Multiple Sclerosis
NCT05718947 ·Status: COMPLETED
-
Progression of Cognitive and Physical Symptoms in Multiple Sclerosis
NCT00922831 ·Status: WITHDRAWN
-
Cortical Inhibition in Patients With Multiple Sclerosis
NCT07128160 ·Status: NOT_YET_RECRUITING
-
Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD20 Therapies
NCT06526000 ·Status: COMPLETED
-
Spinal Cord Analysis in Multiple Sclerosis
NCT03841903 ·Status: COMPLETED
-
Grey Matter Damage at the Earliest Phase of Multiple Sclerosis : a Longitudinal 7T MRI Study
NCT03659981 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Magnetic Resonance Imaging (MRI) Follow-up of Macrophagic Infiltration in MS Patients Treated With Tysabri
NCT00752778 ·Status: TERMINATED ·Phase: PHASE4
-
MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis
NCT03356366 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Evaluation of the Positron Emission Tomography (PET) Tracer ZK 6032924 in Patients With Multiple Sclerosis Compared to Healthy Volunteers
NCT01031199 ·Status: COMPLETED ·Phase: PHASE1