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Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

NCT00005900 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2005-06-24

No results posted yet for this study

Summary

OBJECTIVES: I. Evaluate bronchoalveolar lavage fluid and serum obtained from pediatric patients with storage disorders prior to allogeneic hematopoietic stem cell transplantation (HSCT) for the presence of proinflammatory cytokines and for the production of nitric oxide by alveolar macrophages to identify possible risk factors for pulmonary complications.

II. Investigate the underlying mechanism for the development of significant pulmonary complications in these patients during HSCT.

III. Evaluate bronchoalveolar lavage fluid and serum obtained from these same patients at the time a pulmonary complication develops post-HSCT, or at 60 days post-HSCT if there has been no pulmonary complications.

Conditions

  • I Cell Disease
  • Fucosidosis
  • Globoid Cell Leukodystrophy
  • Adrenoleukodystrophy
  • Mannosidosis
  • Niemann-Pick Disease
  • Pulmonary Complications
  • Mucopolysaccharidosis I
  • Mucopolysaccharidosis VI
  • Metachromatic Leukodystrophy
  • Gaucher's Disease
  • Wolman Disease

Sponsors & Collaborators

  • Fairview University Medical Center

    lead OTHER

Principal Investigators

  • K. Scott Baker · Fairview University Medical Center

Eligibility

Min Age
0 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00005900 on ClinicalTrials.gov