Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer

NCT00005583 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2013-08-02

No results posted yet for this study

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether radiation therapy with chemotherapy is more effective than radiation therapy alone in treating high-risk endometrial cancer.

PURPOSE: This randomized phase III trial is studying radiation therapy and chemotherapy to see how well they work compared to radiation therapy alone in treating patients with high-risk endometrial cancer.

Conditions

Endometrial Cancer

Interventions

DRUG: cisplatin
DRUG: doxorubicin hydrochloride
DRUG: epirubicin hydrochloride
PROCEDURE: adjuvant therapy
PROCEDURE: conventional surgery
RADIATION: radiation therapy

Sponsors & Collaborators

European Organisation for Research and Treatment of Cancer - EORTC
collaborator NETWORK
Nordic Society of Gynaecological Oncology - Clinical Trials Unit
lead OTHER

Principal Investigators

Gunnar B. Kristensen, MD, PhD · Norwegian Radium Hospital
Carlos F. de Oliveira, MD, PhD · Hospitais da Universidade de Coimbra (HUC)

Study Design

Allocation: RANDOMIZED
Purpose: TREATMENT
Masking: NONE

Eligibility

Sex: FEMALE
Healthy Volunteers: No

Timeline & Regulatory

Start: 2000-01-31
Completion: 2010-07-31

Countries

Belgium
France
Ireland
Italy
Netherlands
Norway
Poland
Portugal
South Africa
Spain
United Kingdom

Study Locations

More Related Trials

Entities

Drugs

Cisplatin

Diseases

Endometrial Cancer