O6-benzylguanine and Carmustine in Treating Patients With Recurrent, Metastatic, or Locally Advanced Soft Tissue Sarcoma
NCT00005066 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2013-09-05
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining O6-benzylguanine and carmustine in treating patients who have recurrent, metastatic, or locally advanced soft tissue sarcoma.
Conditions
- Sarcoma
Interventions
- DRUG
-
O6-benzylguanine
- DRUG
-
carmustine
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
University of Chicago
lead OTHER
Principal Investigators
-
Walter M. Stadler, MD, FACP · University of Chicago
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2000-06-30
- Primary Completion
- 2001-09-30
- Completion
- 2002-10-31
Countries
- United States
Study Locations
More Related Trials
-
Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus
NCT00033644 ·Status: TERMINATED ·Phase: PHASE2
-
BMS-247550 in Treating Patients With Advanced Soft Tissue Sarcoma
NCT00022542 ·Status: TERMINATED ·Phase: PHASE2
-
Ifosfamide With or Without O(6)-Benzylguanine in Treating Patients With Unresectable, Metastatic Solid Tumors
NCT00086970 ·Status: TERMINATED ·Phase: PHASE1
-
Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
NCT00005796 ·Status: COMPLETED ·Phase: PHASE1
-
Inhaled Sargramostim in Treating Patients With First Pulmonary (Lung) Recurrence of Osteosarcoma
NCT00066365 ·Status: COMPLETED ·Phase: PHASE2
-
Mithramycin for Children and Adults With Solid Tumors or Ewing Sarcoma
NCT01610570 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
NCT00003567 ·Status: TERMINATED ·Phase: PHASE1
-
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
NCT04222413 ·Status: RECRUITING ·Phase: PHASE1
-
Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma
NCT02306161 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer
NCT00014573 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma
NCT00004066 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma
NCT00002601 ·Status: COMPLETED ·Phase: PHASE2
-
Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma
NCT00002641 ·Status: COMPLETED ·Phase: PHASE3
-
Dinutuximab in Combination With Sargramostim in Treating Patients With Recurrent Osteosarcoma
NCT02484443 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma
NCT00023738 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma
NCT01795430 ·Status: WITHDRAWN ·Phase: NA
-
Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas
NCT00253487 ·Status: COMPLETED ·Phase: NA
-
Combination Chemotherapy, Bone Marrow or Peripheral Stem Cell Transplantation, and/or Biological Therapy in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma
NCT00004231 ·Status: COMPLETED ·Phase: PHASE2
-
Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal Tumors
NCT00003846 ·Status: COMPLETED ·Phase: PHASE2
-
Targeting Microenvironment and Cellular Immunity in Sarcomas Weekly Trabectedin Combined With Metronomic Cyclophosphamide
NCT02805725 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Chemo-immunotherapy in Patients Under 18 Years of Age With Bone and Soft Tissue Sarcomas
NCT06669013 ·Status: RECRUITING ·Phase: PHASE3
-
Combination Chemotherapy With or Without Biological Therapy in Treating Patients With Refractory Solid Tumor or Lymphoma
NCT00005021 ·Status: COMPLETED ·Phase: PHASE1
-
PP-Gemcitabine & External Beam Radiation-Sarcomas
NCT02046304 ·Status: COMPLETED ·Phase: PHASE1
-
Chemotherapy in Treating Patients With Advanced Sarcoma
NCT00002526 ·Status: COMPLETED ·Phase: PHASE2
-
Topotecan Plus Sargramostim in Treating Patients With Advanced Cancer
NCT00002950 ·Status: COMPLETED ·Phase: PHASE1/PHASE2