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Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma

NCT00002641 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 350

Last updated 2014-08-08

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether giving chemotherapy after surgery is more effective than surgery alone in treating soft tissue sarcoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of surgery with or without chemotherapy in treating patients who have soft tissue sarcoma.

Conditions

Interventions

BIOLOGICAL

filgrastim

DRUG

doxorubicin hydrochloride

DRUG

ifosfamide

DRUG

isolated perfusion

PROCEDURE

adjuvant therapy

PROCEDURE

conventional surgery

RADIATION

radiation therapy

Sponsors & Collaborators

  • NCIC Clinical Trials Group

    collaborator NETWORK

  • European Organisation for Research and Treatment of Cancer - EORTC

    lead NETWORK

Principal Investigators

  • Penella J. Woll, MD, PhD · Cancer Research Centre at Weston Park Hospital

  • Vivien H.C. Bramwell, MB, BS, PhD, FRCP · Tom Baker Cancer Centre - Calgary

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT

Eligibility

Min Age
16 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1995-02-28
Primary Completion
2006-02-28
Completion
2012-06-30

Countries

  • Austria
  • Belgium
  • Canada
  • Denmark
  • France
  • Germany
  • Italy
  • Netherlands
  • Portugal
  • Slovakia
  • Spain
  • Switzerland
  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00002641 on ClinicalTrials.gov