Calcitriol and Zoledronate in Treating Patients With Progressive Prostate Cancer
NCT00004928 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2013-06-19
Summary
RATIONALE: Calcitriol may help prostate cancer cells develop into normal cells. Zoledronate may delay or prevent the formation of bone metastases. Combining calcitriol and zoledronate may be an effective treatment for progressive prostate cancer.
PURPOSE: Phase I trial to study the effectiveness of combining calcitriol with zoledronate in treating patients who have progressive prostate cancer.
Conditions
Interventions
- DIETARY_SUPPLEMENT
-
calcitriol
- DRUG
-
zoledronic acid
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Michael Morris, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- MALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1999-10-31
- Primary Completion
- 2004-10-31
- Completion
- 2004-10-31
Countries
- United States
Study Locations
More Related Trials
-
Study of Zoledronic Acid for Patients With Hormone-sensitive Bone Metastases From Prostate Cancer
NCT00242567 ·Status: COMPLETED ·Phase: PHASE3
-
The Effect of Zoledronic Acid on Bone Loss in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
NCT00063609 ·Status: COMPLETED ·Phase: PHASE4
-
Calcitriol Plus Dexamethasone in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy
NCT00010231 ·Status: COMPLETED ·Phase: PHASE1
-
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
NCT00520052 ·Status: COMPLETED ·Phase: NA
-
Study on Evaluation of Zoledronic Acid to Prevent Bone Loss in Men Receiving Androgen Deprivation Therapy for Prostate Cancer
NCT00489905 ·Status: COMPLETED ·Phase: NA
-
Zoledronate Plus Standard Therapy Compared With Placebo Plus Standard Therapy to Prevent Bone Metastases in Patients With Recurrent Prostate Cancer That Has No Symptoms
NCT00005073 ·Status: TERMINATED ·Phase: PHASE3
-
Calcitriol, Mitoxantrone, and Prednisone in Treating Patients With Metastatic Prostate Cancer
NCT00182741 ·Status: COMPLETED ·Phase: PHASE2
-
Calcitriol in Preventing Prostate Cancer in Patients With Prostatic Intraepithelial Neoplasia
NCT00118066 ·Status: TERMINATED ·Phase: PHASE2
-
Calcitriol and Dexamethasone Before Radical Prostatectomy in Treating Patients With Localized Adenocarcinoma (Cancer) of the Prostate
NCT00084864 ·Status: TERMINATED ·Phase: PHASE2
-
Calcitriol and Dexamethasone in Treating Patients With Prostate Cancer Who Have Undergone Surgery or Radiation Therapy
NCT00054522 ·Status: COMPLETED ·Phase: PHASE2
-
Maintaining Bone Strength in Men With Prostate Cancer
NCT00391950 ·Status: TERMINATED ·Phase: PHASE3
-
Androgen Blockade Therapy With or Without Zoledronic Acid in Treating Patients With Prostate Cancer and Bone Metastases
NCT00685646 ·Status: COMPLETED ·Phase: PHASE3
-
Zoledronic Acid With Intermittent Hormonal Therapy in Patients With Prostate Cancer
NCT00226954 ·Status: TERMINATED ·Phase: PHASE2
-
Calcitriol and Carboplatin in Treating Patients With Stage IV Prostate Cancer That Has Not Responded to Hormone Therapy
NCT00017576 ·Status: COMPLETED ·Phase: PHASE2
-
Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating Patients With Prostate Cancer
NCT00536991 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Prostate Cancer Study in Men Undergoing Androgen Deprivation Therapy
NCT00087659 ·Status: COMPLETED ·Phase: NA
-
A Study to Evaluate the Efficacy and Tolerability of Zoledronic Acid in Patients With Metastatic Prostate Cancer Who Can be Treated With a Group of Medications Known as Bisphosphonates
NCT00172016 ·Status: COMPLETED ·Phase: PHASE4
-
Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases
NCT00081159 ·Status: COMPLETED ·Phase: PHASE2
-
Calcitriol or Placebo in Men for Prostate Cancer Active Surveillance
NCT00482157 ·Status: WITHDRAWN ·Phase: NA
-
Paricalcitol in Treating Patients With Advanced Prostate Cancer and Bone Metastases
NCT00634582 ·Status: TERMINATED ·Phase: PHASE2
-
Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer
NCT00334139 ·Status: COMPLETED ·Phase: PHASE4
-
Open-label Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastases
NCT00242554 ·Status: COMPLETED ·Phase: PHASE4
-
Cholecalciferol Supplement in Treating Patients With Localized Prostate Cancer Undergoing Observation
NCT00887432 ·Status: COMPLETED ·Phase: NA
-
Zometa on Bone Mineral Density in Prostate Cancer Patients Undergoing Androgen Ablation Therapy
NCT00582556 ·Status: COMPLETED ·Phase: PHASE2
-
Duration of Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Men With Metastatic CRPC
NCT01062503 ·Status: COMPLETED