Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer
NCT00334139 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 411
Last updated 2017-02-07
Summary
Bisphosphonates have been used extensively in the treatment and the prevention of skeletal complications associated with bone metastases in patients with breast cancer and prostate cancer.
The purpose of this study is to assess the effect of zoledronic acid patients with prostate cancer or breast cancer and bone metastasis.
Conditions
- Prostate Cancer
- Breast Cancer
- Bone Metastasis
Interventions
- DRUG
-
Zoledronic Acid
every 4 weeks for 4 months
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Novartis Pharmeceuticals
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-05-31
- Primary Completion
- 2009-07-31
- Completion
- 2009-07-31
Countries
- Germany
Study Locations
More Related Trials
-
Evaluation of Bone Markers as Diagnostic Tools for Early Detection of Bone Metastases in Patients With High Risk Prostate Cancer
NCT00391690 ·Status: COMPLETED ·Phase: PHASE4
-
Zoledronate in Preventing Skeletal (Bone)-Related Events in Men Who Are Receiving Androgen Deprivation Therapy For Prostate Cancer and Bone Metastases
NCT00079001 ·Status: COMPLETED ·Phase: PHASE3
-
Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer
NCT00181584 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Evaluate Zoledronic Acid on Quality of Life and Skeletal-related Events as Adjuvant Treatment in Patients With Hormone-naïve Prostate Cancer and Bone Metastasis Who Have Undergone Orchiectomy
NCT00237146 ·Status: COMPLETED ·Phase: PHASE4
-
Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy
NCT00172055 ·Status: COMPLETED ·Phase: PHASE3
-
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
NCT00520052 ·Status: COMPLETED ·Phase: NA
-
Open-label Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastases
NCT00242554 ·Status: COMPLETED ·Phase: PHASE4
-
Zoledronate Plus Standard Therapy Compared With Placebo Plus Standard Therapy to Prevent Bone Metastases in Patients With Recurrent Prostate Cancer That Has No Symptoms
NCT00005073 ·Status: TERMINATED ·Phase: PHASE3
-
Study of Zoledronic Acid for Patients With Hormone-sensitive Bone Metastases From Prostate Cancer
NCT00242567 ·Status: COMPLETED ·Phase: PHASE3
-
Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Density in Hormone Sensitive Prostate Cancer Patients With Bone Metastasis
NCT00035997 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Zoledronic Acid in the Treatment of Bone Metastases-related Pain in Patients With Prostate Cancer
NCT00375648 ·Status: COMPLETED ·Phase: PHASE3
-
The Effect of Zoledronic Acid on Bone Loss in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
NCT00063609 ·Status: COMPLETED ·Phase: PHASE4
-
The Use of Zoledronic Acid in Men on Androgen Deprivation Therapy for Prostate Cancer With Preexisting Osteoporosis
NCT00171639 ·Status: COMPLETED ·Phase: PHASE3
-
ZANTE: Zometa and Taxotere in Hormone Refractory Prostate Cancer
NCT00415779 ·Status: COMPLETED ·Phase: PHASE1
-
Atrasentan and Zometa for Men With Prostate Cancer Metastatic to Bone
NCT00181558 ·Status: COMPLETED ·Phase: PHASE2
-
Radium-223 and Radiotherapy in Hormone-Naïve Men With Oligometastatic Prostate Cancer to Bone
NCT03304418 ·Status: COMPLETED ·Phase: PHASE2
-
Effect Of Zoledronic Acid On Circulating And Bone Marrow-Residing Prostate Cancer Cells In Patients With Clinically Localized Prostate Cancer
NCT00219271 ·Status: COMPLETED ·Phase: PHASE4
-
Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases
NCT00081159 ·Status: COMPLETED ·Phase: PHASE2
-
Study on Evaluation of Zoledronic Acid to Prevent Bone Loss in Men Receiving Androgen Deprivation Therapy for Prostate Cancer
NCT00489905 ·Status: COMPLETED ·Phase: NA
-
Zoledronic Acid With Intermittent Hormonal Therapy in Patients With Prostate Cancer
NCT00226954 ·Status: TERMINATED ·Phase: PHASE2
-
Effect of Androgen Suppression on Bone Loss in Patients With or Without Bone Metastases Secondary to Prostate Cancer
NCT00003903 ·Status: COMPLETED ·Phase: NA
-
Duration of Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Men With Metastatic CRPC
NCT01062503 ·Status: COMPLETED
-
S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy
NCT00134056 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase II Neoadjuvant Study of Darolutamide Plus ADT in Men With Localized Prostate Cancer
NCT06029036 ·Status: RECRUITING ·Phase: PHASE2
-
Phase I Study of ZD4054 (Zibotentan) and Docetaxel in Patients With Metastatic HRPC
NCT00314782 ·Status: COMPLETED ·Phase: PHASE1