Fluorouracil Plus UCN-01 in Treating Patients With Advanced or Refractory Solid Tumors
NCT00004059 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2013-06-21
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. UCN-01 may increase the effectiveness of a chemotherapy drug by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the effectiveness of fluorouracil plus UCN-01 in treating patients who have advanced or refractory solid tumors.
Conditions
- Unspecified Adult Solid Tumor, Protocol Specific
Interventions
- DRUG
-
7-hydroxystaurosporine
- DRUG
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Gary K. Schwartz, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1999-07-31
- Primary Completion
- 2002-09-30
- Completion
- 2002-09-30
Countries
- United States
Study Locations
More Related Trials
-
Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer
NCT07042685 ·Status: RECRUITING ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors
NCT00020488 ·Status: COMPLETED ·Phase: PHASE1
-
Fluorouracil Plus Interferon Alfa in Treating Patients With Advanced Metastatic Carcinoid Tumors
NCT00002470 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
NCT00003594 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors
NCT00001579 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus
NCT00005607 ·Status: UNKNOWN ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Advanced Cancer
NCT00021073 ·Status: COMPLETED ·Phase: PHASE1
-
Study of NK012 and 5-FU/LV in Solid Tumors Followed by Dose Expansion in Colorectal Cancer
NCT01238939 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors
NCT00042874 ·Status: COMPLETED ·Phase: PHASE1
-
Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon Cancer
NCT00004931 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
NCT00039611 ·Status: COMPLETED ·Phase: NA
-
Phase I Study of PN401, Fluorouracil, Leucovorin and CPT-11 in Patients With Solid Tumors
NCT00044785 ·Status: TERMINATED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Stage III Colon Cancer
NCT00003835 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
NCT00003001 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer
NCT00003175 ·Status: COMPLETED ·Phase: PHASE2
-
Study of 5-Fluorouracil and Leucovorin and Intra-abdominal Floxuridine Chemoradiation in Patients With Fully Resected Locally Advanced Gastric Adenocarcinoma
NCT00183911 ·Status: COMPLETED ·Phase: PHASE2
-
Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer
NCT06654037 ·Status: RECRUITING ·Phase: PHASE1
-
Alvocidib in Treating Patients With Locally Advanced or Metastatic Solid Tumors
NCT00112684 ·Status: TERMINATED ·Phase: PHASE1
-
Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin
NCT00004005 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy With Raltitrexed and Fluorouracil in Treating Patients With Advanced Colorectal Cancer
NCT00002828 ·Status: COMPLETED ·Phase: PHASE1
-
Alvocidib in Treating Patients With Metastatic or Unresectable Refractory Solid Tumors or Hematologic Malignancies
NCT00070239 ·Status: TERMINATED ·Phase: PHASE1
-
Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid Tumors
NCT00138177 ·Status: COMPLETED ·Phase: PHASE1
-
Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer
NCT00003873 ·Status: COMPLETED ·Phase: PHASE3
-
CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
NCT02232152 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer
NCT06833866 ·Status: RECRUITING ·Phase: PHASE1