Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers
NCT00002752 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL
Last updated 2014-07-16
Summary
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
PURPOSE: Phase I/II trial to study the effectiveness of radiolabeled monoclonal antibody therapy in treating patients who have primary or metastatic brain cancer.
Conditions
Interventions
- RADIATION
-
iodine I 131 monoclonal antibody 81C6
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Darell D. Bigner, MD, PhD · Duke Cancer Institute
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 3 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1993-02-28
- Primary Completion
- 2003-01-31
- Completion
- 2010-03-31
Countries
- United States
Study Locations
More Related Trials
-
Stereotactic Radiosurgery in Treating Patients With Brain Metastases
NCT00811655 ·Status: TERMINATED ·Phase: PHASE2
-
Iodine I 131 Monoclonal Antibody TNT-1/B in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
NCT00128635 ·Status: COMPLETED ·Phase: PHASE1
-
Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer
NCT00089245 ·Status: TERMINATED ·Phase: PHASE1
-
Stereotactic Radiosurgery After Surgery in Treating Patients With Brain Metastases
NCT00814463 ·Status: TERMINATED ·Phase: PHASE2
-
Stereotactic Radiosurgery in Treating Patients With Brain Tumors
NCT00019578 ·Status: COMPLETED ·Phase: PHASE1
-
Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma
NCT00058370 ·Status: COMPLETED ·Phase: NA
-
Beta-Glucan and Monoclonal Antibody in Treating Patients With Metastatic Neuroblastoma
NCT00037011 ·Status: COMPLETED ·Phase: PHASE1
-
Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
NCT01502917 ·Status: COMPLETED ·Phase: PHASE1
-
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases
NCT01644591 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET)
NCT01542736 ·Status: COMPLETED ·Phase: PHASE2
-
Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain
NCT00039572 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
NCT02208362 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM
NCT04991870 ·Status: RECRUITING ·Phase: PHASE1
-
Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery
NCT01372774 ·Status: COMPLETED ·Phase: PHASE3
-
Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Newly Diagnosed Glioblastoma
NCT03400917 ·Status: UNKNOWN ·Phase: PHASE2
-
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
NCT04690348 ·Status: RECRUITING ·Phase: PHASE2
-
Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma
NCT04661384 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas
NCT01107522 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Bispecific Antibody Plus White Blood Cells in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme
NCT00005813 ·Status: COMPLETED ·Phase: PHASE1
-
Fractionated Stereotactic Radiosurgery With Concurrent Bevacizumab for Brain Metastases: A Phase I Dose-escalation Trial
NCT02672995 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme
NCT01268566 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy in Treating Patients With Recurrent Malignant Glioma
NCT00002986 ·Status: COMPLETED ·Phase: PHASE1
-
Neoadjuvant Immunotherapy in Brain Metastases
NCT04434560 ·Status: TERMINATED ·Phase: PHASE2
-
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
NCT01891318 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Carbon Ion Radiotherapy for Primary Glioblastoma
NCT01165671 ·Status: COMPLETED ·Phase: NA