A Study of AZT Plus Ganciclovir in Patients With AIDS and Cytomegalovirus (CMV) Infection
NCT00000995 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2021-11-04
Summary
To evaluate the clinical and laboratory toxicity of ganciclovir (GCV) and zidovudine (AZT) when given in combination.
Because recent information has shown AZT to be useful in treating AIDS, it is assumed that most patients with AIDS, and probably with AIDS related complex (ARC), will be receiving AZT. Because AZT is reported not to be active against cytomegalovirus (CMV), it is important to see if it is useful to give GCV along with AZT.
Conditions
- Cytomegalovirus Infections
- HIV Infections
Interventions
- DRUG
-
Zidovudine
- DRUG
-
Ganciclovir
Sponsors & Collaborators
-
National Institute of Allergy and Infectious Diseases (NIAID)
lead NIH
Principal Investigators
-
Reichman RC
-
Richman D
-
Hochster H
Study Design
- Purpose
- TREATMENT
- Masking
- NONE
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Completion
- 1990-02-28
Countries
- United States
Study Locations
More Related Trials
-
A Randomized Controlled Study of the Efficacy and Safety of Maintenance Treatment With Oral Ganciclovir for Newly Diagnosed Cytomegalovirus Retinitis in People With AIDS
NCT00002257 ·Status: COMPLETED ·Phase: NA
-
A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
NCT00002330 ·Status: COMPLETED ·Phase: NA
-
A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Large Intestine in Patients With AIDS
NCT00002273 ·Status: COMPLETED ·Phase: NA
-
A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS
NCT00002034 ·Status: COMPLETED ·Phase: NA
-
A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy
NCT00000673 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of HIV and Cytomegalovirus (CMV) in HIV-Infected Patients
NCT00001089 ·Status: COMPLETED
-
A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV Retinitis
NCT00000698 ·Status: COMPLETED ·Phase: PHASE3
-
A Randomized, Controlled Study of the Safety and Preventive Efficacy of Oral Ganciclovir When Used in Conjunction With An Intravitreal Ganciclovir Implant in the Treatment of Cytomegalovirus Retinitis
NCT00002134 ·Status: COMPLETED ·Phase: NA
-
The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV
NCT00001034 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With Ganciclovir
NCT00000970 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes
NCT00001062 ·Status: COMPLETED ·Phase: PHASE1
-
Kinetics of Response of Cytomegalovirus With Ganciclovir Treatment Using Quantitative Real-Time PCR
NCT00004573 ·Status: UNKNOWN ·Phase: NA
-
Preventing Cytomegalovirus (CMV) Organ Damage With Valganciclovir in People With HIV
NCT00006145 ·Status: COMPLETED ·Phase: PHASE3
-
The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
NCT00002299 ·Status: COMPLETED ·Phase: NA
-
A Randomized Study Comparing the Safety and Efficacy of Two Regimens of Oral Ganciclovir to Intravenous Ganciclovir Maintenance Therapy for Cytomegalovirus Retinitis in People With AIDS Who Have Received Prior Ganciclovir Therapy
NCT00002247 ·Status: COMPLETED ·Phase: NA
-
A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Peripheral Cytomegalovirus Retinitis in Patients With AIDS
NCT00000688 ·Status: COMPLETED ·Phase: PHASE3
-
Ganciclovir Implant Study for Cytomegalovirus Retinitis
NCT00000118 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir
NCT00000668 ·Status: COMPLETED ·Phase: PHASE1
-
Impact of CMV Status on HIV Viral Load Decay
NCT03349359 ·Status: COMPLETED
-
Comparison of Two Methods in the Treatment of Cytomegalovirus of the Eyes in Patients With AIDS
NCT00001061 ·Status: COMPLETED ·Phase: PHASE2
-
A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
NCT00000768 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure
NCT00000691 ·Status: COMPLETED ·Phase: PHASE2
-
CMV Glycoprotein B Vaccine in Allograft Recipients
NCT00299260 ·Status: UNKNOWN ·Phase: PHASE2
-
An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients
NCT00002039 ·Status: COMPLETED ·Phase: NA
-
A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
NCT00000881 ·Status: WITHDRAWN ·Phase: PHASE1