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Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

NCT00000250 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2015-05-28

No results posted yet for this study

Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Conditions

  • Opioid-Related Disorders
  • Substance-Related Disorders

Interventions

DRUG

0% N2O

Subjects will inhale 100% oxygen with no N2O for 25 min then immerse forearm in warm water and cold water

DRUG

40% N2O

Subjects will inhale 40% N2O then immerse forearm in warm water and cold water

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • University of Chicago

    lead OTHER

Principal Investigators

  • James Zacny, Ph.D. · University of Chicago

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
32 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1993-12-31
Primary Completion
1995-05-31
Completion
1995-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00000250 on ClinicalTrials.gov