News & Analysis

Curated news and analysis on clinical trials, drug approvals, and medical research.

Recent Cancer Research Advances Span Treatments and Biomarkers

A phase one trial of RSO-021 achieved disease control in 67% of relapsed mesothelioma patients. Other advances include daraxonrasib for NRAS-driven melanoma, an aneuploidy biomarker for PARP inhibitor response in childhood cancers, and new research into a cancer target and cholangiocarcinoma treatment.

Senate Hearing on COVID Vaccine Adverse Events; Study IDs Blood Clot Trigger

A Senate subcommittee heard testimony that mRNA COVID vaccines were considered the likely cause in 73.9% of post-vaccine deaths in a large autopsy series. Separately, NEJM research identified the K31E antibody mutation and adenovirus protein pVII as triggers of rare VITT blood clots. The findings may enable safer adenoviral vaccines.

Experts Warn Hepatitis B Treatment Too Complex; Philippines Faces High Burden

In the Philippines, an estimated 7.3 million adults live with chronic hepatitis B, far above regional averages. Experts warn that complex treatment guidelines may hinder front-line clinicians from initiating care, while Thailand’s success with vaccination shows a path to elimination. Expanding screening and simplifying treatment are critical steps.

Innovative Funding and Digital Twins Drive Rare Disease Drug Development

New investment models and digital twin technologies are bridging gaps in rare disease drug development, where traditional funding and trial designs fall short. Patient-led funding and family offices provide capital, while regulators accept digital evidence to accelerate therapies for the more than 7,000 rare diseases with few approved treatments.

Study: Beyfortus Reduces RSV Hospitalizations Over Two Seasons Amid FDA Warning

A real-world study in Galicia showed nirsevimab reduced RSV-related hospitalizations by 85.9% in the first season and 55.3% in the second. The RSV prevention market is expanding to cover high-risk children, with Beyfortus the only antibody approved for second-season use. The FDA has cited Sanofi for misleading promotional claims about the product.

St. Jude Researchers Lead Global Consensus Guidelines for Pediatric Diseases

St. Jude Children’s Research Hospital experts are creating evidence-informed consensus guidelines covering brain tumor diagnosis, pharmacogenomics, survivorship care, and rare blood disorders. Their work helps clinicians translate the latest data into improved diagnosis, treatment, and follow-up care globally.

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