TNF Blockade

Mechanism

Also known as: TNF blockade

Related News

Study identifies path to reduce immune checkpoint inhibitor heart toxicity

Apr 11, 2026

A Feb. 20, 2026 study in the Journal of Experimental Medicine identified CD8 T cell-derived TNF and TNFR2 signaling as drivers of ICI-related myocarditis in mice. Blocking TNFR2 prevented the inflammatory cycle in the heart.

Discovery Shows How to Prevent Fatal Heart Inflammation from Cancer Immunotherapy

Mar 19, 2026

Scientists at Cincinnati Children's have identified a molecular pathway responsible for immune checkpoint inhibitor-induced myocarditis and demonstrated that blocking TNF signaling can prevent this fatal complication without compromising anti-tumor efficacy.