News Related to targeted therapies

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Many Cancer Patients Miss Genomic Testing, Study Finds

Apr 08, 2026

A JAMA Network Open study reveals roughly half of metastatic cancer patients receive genomic testing, with disparities affecting low-income, Medicare/Medicaid, and minority patients. The research highlights gaps in accessing targeted therapies despite cancer survival improvements.

Clinical Trial Advances in Cancer Immunotherapy and Targeted Therapies

Apr 02, 2026

Moderna and Merck advance a Phase 2 trial of mRNA cancer vaccine V940 with pembrolizumab and chemotherapy for metastatic squamous NSCLC. In biliary tract cancer, first-line treatment combines chemotherapy with immunotherapy, while targeted therapy resistance prompts liquid biopsy. ImmunityBio tests a chemotherapy-free NK-cell regimen in non-Hodgkin lymphoma.

Cardiovascular Risks Common With BRAF/MEK Inhibitors in Melanoma Patients

Mar 31, 2026

A study finds nearly half of melanoma patients receiving BRAF or MEK inhibitors develop hypertension or cardiac dysfunction. Moderate to severe cardiac issues appear within 4 weeks and only in patients with medium or higher baseline risk. Higher baseline NT-proBNP levels are associated with increased cardiac dysfunction risk.

Osimertinib-Chemotherapy Combo Shows Major Benefit in High-Risk EGFR/TP53 NSCLC

Mar 28, 2026

The phase III TOP study shows osimertinib plus chemotherapy more than doubles progression-free survival to 34 months versus 15.6 months with osimertinib alone in EGFR/TP53 mutant NSCLC. The combination achieved an 82.9% response rate and represents a new strategy for this high-risk subgroup. Research continues into resistance mechanisms, including cancer-associated fibroblasts' role in promoting osimertinib resistance.

Orphan Drugs Market Projected to Reach $486.51 Billion by 2032

Mar 23, 2026

The global orphan drugs market is projected to grow from $223.76 billion in 2023 to $486.51 billion by 2032, with North America leading at 38% market share. Over 500 orphan drugs are approved with more than 800 candidates in clinical trials, driven by regulatory incentives and major pharmaceutical company investments in rare disease therapies.

Precision Oncology Extends Survival for Lung Cancer Brain Metastases

Feb 20, 2026

Precision oncology has transformed brain metastases treatment from lung cancer, extending survival from 6-12 months to 3-5 years through targeted therapies, immunotherapy, and radiosurgery. With 100,000-200,000 annual cases in the US, multidisciplinary approaches now manage this once-terminal condition as a chronic disease.