News Related to Copper-Catalyzed Enantioselective Alkylation

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Researchers Develop New Methods for Chiral Sulfur Compounds with Antiviral Potential

Mar 25, 2026

Two research teams have developed catalytic methods for synthesizing chiral sulfur compounds with antiviral potential. One approach uses an organocatalytic strategy to create vinyl sulfinamides that bind to SARS-CoV-2 and HIV-1 proteins, while another employs copper catalysis for high-yield production of chiral sulfilimines. Both methods address critical gaps in accessing valuable chemical space for drug discovery.

New Skeletal Editing Methods Advance Drug Discovery Chemistry

Feb 24, 2026

Three new chemical synthesis methods enable skeletal editing of molecular structures for drug discovery, including photochemical conversion of nitroarenes to azepines, enantioselective S-alkylation of sulfenamides, and O-to-N exchange in cyclic ethers.