News Related to CD19-directed CAR-T therapy

Denileukin Diftitox Shows Promise Before CAR-T Therapy in High-Risk DLBCL

Mar 25, 2026

A phase 1 trial shows denileukin diftitox administered before CAR-T therapy has a favorable safety profile and encouraging efficacy in high-risk DLBCL patients, with an 86% overall response rate and 77% one-year progression-free survival. The treatment demonstrated consistent regulatory T-cell depletion, supporting its immunomodulatory mechanism. Larger controlled studies are needed to confirm these preliminary findings.

Cell Therapy Market Growth Accelerates with CAR-T Dominance and New Research Milestones

Mar 24, 2026

The cell therapy manufacturing market is projected to reach $14.01 billion by 2035, with CAR-T therapies dominating at 65% market share. Recent FDA approvals for new CAR-T indications and Japanese regulatory acceleration highlight growing clinical adoption, while research advances include new anti-aging protein platforms and CRISPR-based treatments.

Citius Oncology Reports LYMPHIR Revenue and Positive Phase 1 CAR-T Combination Data

Mar 04, 2026

Citius Pharmaceuticals reported $3.9 million in first revenue from LYMPHIR's December 2025 launch for cutaneous T-cell lymphoma, while subsidiary Citius Oncology announced positive Phase 1 data showing 86% response rate when LYMPHIR was administered prior to CAR-T therapy in high-risk lymphoma patients.