Novel Antimicrobial Peptide GT-2 Achieves Broad-Spectrum Activity with Lipid-Dependent Selectivity
A newly reported antimicrobial peptide, GT-2, selectively disrupts microbial membranes while sparing mammalian cells. The peptide adopts a helical conformation in response to bacterial and fungal lipids and reduced Pseudomonas aeruginosa wound burden below the detection limit in a topical model.