News Related to TRPV1

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TRPV4 study identifies a neural 'stop-scratching' mechanism in chronic itch

May 10, 2026

A mouse study identified **TRPV4** as part of the neural feedback system that tells the brain when scratching has been sufficient. The findings suggest broadly blocking TRPV4 may not be the solution for chronic itch.

Orphan Drug Regulators Navigate Uncertainty as Definitions and Pathways Diverge Globally

Feb 26, 2026

Orphan drug development faces structural uncertainty due to small patient populations and varying global definitions, with regulators balancing early access against evidence requirements through accelerated pathways and post-market monitoring.