News Related to alpha-synuclein

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CSF DOPA Decarboxylase Biomarker Shows Strong Diagnostic Potential for Lewy Body Disorders

Jun 07, 2026

A new cerebrospinal fluid biomarker for DOPA decarboxylase (DDC) shows strong diagnostic potential for Lewy body disorders including Parkinson's disease and dementia with Lewy bodies. Validated across multiple cohorts, CSF DDC levels were significantly elevated in these conditions with high diagnostic accuracy. The biomarker correlated with alpha-synuclein pathology but plasma levels showed no diagnostic value.