News Related to Tacrolimus

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Novel GVHD Prevention Regimen Shows Strong Results Without Standard Immunosuppressants

Mar 25, 2026

Interim results from the ABC phase 1/2b trial show a calcineurin inhibitor-free GVHD prevention regimen combining posttransplant cyclophosphamide, bortezomib, and abatacept achieved low GVHD rates and favorable survival outcomes. The approach enables earlier introduction of posttransplant maintenance therapies while reducing toxicity associated with conventional immunosuppressants.

Roche's Gazyva Meets Primary Endpoint in Phase III Kidney Disease Trial

Feb 16, 2026

Roche announced that Gazyva/Gazyvaro met its primary endpoint in the Phase III MAJESTY study for primary membranous nephropathy, showing statistically significant complete remission rates versus tacrolimus. The drug could become the first approved therapy for this rare autoimmune kidney disease.