News Related to Obecabtagene Autoleucel

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CAR-T Cell Therapy Shows Promise in Severe Lupus: Immune Reset, Fertility Preservation

Jul 10, 2026

Phase I CARLYSLE trial data show CAR-T therapy obe-cel induces remission in severe refractory lupus with a favorable safety profile. Separate case report documents two successful pregnancies after dual-target CAR-T therapy with no transmission to infants.

CAR-T toxicity management shifts toward phenotype- and mechanism-based intervention

Apr 24, 2026

CAR-T toxicity management is shifting toward phenotype- and mechanism-based intervention. Key issues include CRS, ICANS, IEC-HS, and long-term risks of cytopenia and infection.