News Related to Nexiguran Ziclumeran

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FDA Lifts Clinical Hold on Intellia's ATTR Cardiomyopathy Trial

Mar 02, 2026

The FDA removed the clinical hold on Intellia Therapeutics' Phase 3 trial of nexiguran ziclumeran for transthyretin amyloidosis with cardiomyopathy. The hold was imposed in October following liver safety concerns in one patient.

FDA Lifts Clinical Hold on Intellia's MAGNITUDE-2 Trial for ATTRv-PN

Feb 28, 2026

The FDA removed the clinical hold on Intellia Therapeutics' MAGNITUDE-2 Phase 3 trial of nexiguran ziclumeran for ATTRv-PN, allowing patient enrollment and dosing to resume with enhanced safety monitoring.