MIL62

Drug

Drug Profile

MIL62 is a glyco-engineered humanized anti-CD20 monoclonal antibody with antineoplastic and immunomodulatory activity. Clinical studies have evaluated MIL62, including combination with lenalidomide, in relapsed/refractory follicular lymphoma and marginal zone lymphoma. Current evidence indicates ongoing late-phase clinical development.

Drug Class
Glyco-engineered humanized anti-CD20 monoclonal antibody
Approval Status
Investigational candidate with ongoing Phase III study; no approved marketing status stated.
Mechanism of Action
Targets CD20 on B cells, inducing antibody-dependent cell-mediated cytotoxicity and apoptosis while inhibiting CD20-mediated proliferative signaling.
Indications
  • \Relapsed/refractory follicular lymphoma (investigational)\
  • \Relapsed/refractory marginal zone lymphoma (investigational)\

Related News

FDA Approves CAR-T Therapy for Marginal Zone Lymphoma, New Myeloma Drug Advances to Phase 2

The FDA has approved Bristol Myers Squibb's CAR-T therapy Breyanzi for relapsed/refractory marginal zone lymphoma, while a novel multiple myeloma drug candidate DTP3 advances to Phase 2 trials after showing promising early results. Both developments represent significant progress in blood cancer treatment, with the marginal zone lymphoma approval based on a 95.5% response rate and the myeloma drug demonstrating selective cancer cell killing without toxicity.

Related Clinical Trials

NCT ID Title Status Phase
NCT07405970

A Phase 3 Clinical Study of MIL62 in Systemic Lupus Erythematosus

RECRUITING PHASE3
NCT05862233

A Phase Ⅲ Clinical Study of MIL62 in Primary Membranous Nephropathy

ACTIVE_NOT_RECRUITING PHASE3
NCT05796206

A Phase 2 Clinical Study of MIL62 in Systemic Lupus Erythematosus

ACTIVE_NOT_RECRUITING PHASE2
NCT05398653

A Phase Ib/ Ⅱ Clinical Study of MIL62 in Primary Membranous Nephropathy

COMPLETED PHASE1/PHASE2
NCT05314010

A Study of MIL62 in Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD)

ACTIVE_NOT_RECRUITING PHASE3